Computationally and statistically efficient model fitting techniques

Computationally and Statistically Efficient Model Fitting Techniques

In large-scale stochastic simulations, analysis with sufficient accuracy is often extremely time consuming. The complexity of the analysis is exacerbated with increasing dimensionality of the parameter space and sudden abruptness in the topology of the input-output response surface. This paper addresses computational issues in fitting and generating error measures of simulation metamodels, demo...

Statistically and Computationally Efficient Variance Estimator for Kernel Ridge

Computationally Efficient Techniques for Structural Optimization

The objective of this paper is to investigate the efficiency of combinatorial optimization methods and in particular algorithms based on evolution strategies, when incorporated into structural optimization problems. Evolution strategies algorithms are used either on a stand-alone basis, or combined with a conventional mathematical programming technique. Furthermore, the structural analysis phas...

A computationally efficient algorithm for fitting ion channel parameters

Continuous time Markov models have been widely used to describe ion channel kinetics, providing explicit representation of channel states and transitions. Fitting models to experimental data remains a computationally demanding task largely due to the high cost of model evaluation. Here, we propose a method to efficiently optimize model parameters and structure. Voltage clamp channel protocols c...

A flexible, computationally efficient method for fitting the proportional hazards model to interval-censored data.

The proportional hazards model (PH) is currently the most popular regression model for analyzing time-to-event data. Despite its popularity, the analysis of interval-censored data under the PH model can be challenging using many available techniques. This article presents a new method for analyzing interval-censored data under the PH model. The proposed approach uses a monotone spline represent...